Open Access
Subscription or Fee Access
PAIN MANAGEMENT IN MICE USING THE AQUEOUS AND ETHANOL EXTRACTS OF FOUR MEDICINAL PLANTS
Abstract
ABSTRACT
Background: There are many traditionally used analgesic plants in Ethiopia. They, however,
have not been subject to scientific investigation for their efficacy and safety.
Objective: To evaluate both prophylactic and relieving effects of aqueous and ethanol
extracts of four traditionally used medicinal plants in Ethiopia.
Design: An experimental design in which five group of albino mice weighing 30-35 grams
representing positive and negative control, and extract treated groups respectively. The
extracts, standard drugs and normal saline were administered into GIT by gavage to evaluate
the analgesic effect.
Setting: Department of Drug Research at Ethiopian Health and Nutrition Research Institute
and Department of Pharmacology at Faculty of Medicine, Addis Ababa university.
Methods: Analgesic effects of water and ethanol extracts of four plants were evaluated
against distilled water and standard analgesics (morphine and acetylsalicylic acid) with
acetic acid induced writhing tests in mice. The four plants used for this screening were
Ocimum sauve, Ocimum lamiifolium, Lippia adoensis and Ajuga remota.
Results: All extracts of the four plant materials were observed to possess both inhibiting and
treatment activities against acetic acid induced pain. Dose related analgesic effect was also
observed with all extracts of all plants with different potencies. Ethanol extracts of all the four
plant materials were more potent than their water extracts at all dose levels except O. sauve,
and L. adoensis whose water extracts seem to be a bit more potent at low dose. The analgesic
potencies of both extracts of all the four plants were shown to be less than those of the
standard analgesics. Of all the extracts, the ethanol extract of O. lamiifolium was found to be
the most potent, while its water extract was the least. Acetic acid induced writhing was
relieved with medium dose of both extracts in most cases and with low dose in few. Hundred
percent relief was achieved with both standard analgesics at a very low dose.
Conclusion: The present study show that all the extracts of all the plant materials have got
both inhibiting and relieving effects of pain.
Background: There are many traditionally used analgesic plants in Ethiopia. They, however,
have not been subject to scientific investigation for their efficacy and safety.
Objective: To evaluate both prophylactic and relieving effects of aqueous and ethanol
extracts of four traditionally used medicinal plants in Ethiopia.
Design: An experimental design in which five group of albino mice weighing 30-35 grams
representing positive and negative control, and extract treated groups respectively. The
extracts, standard drugs and normal saline were administered into GIT by gavage to evaluate
the analgesic effect.
Setting: Department of Drug Research at Ethiopian Health and Nutrition Research Institute
and Department of Pharmacology at Faculty of Medicine, Addis Ababa university.
Methods: Analgesic effects of water and ethanol extracts of four plants were evaluated
against distilled water and standard analgesics (morphine and acetylsalicylic acid) with
acetic acid induced writhing tests in mice. The four plants used for this screening were
Ocimum sauve, Ocimum lamiifolium, Lippia adoensis and Ajuga remota.
Results: All extracts of the four plant materials were observed to possess both inhibiting and
treatment activities against acetic acid induced pain. Dose related analgesic effect was also
observed with all extracts of all plants with different potencies. Ethanol extracts of all the four
plant materials were more potent than their water extracts at all dose levels except O. sauve,
and L. adoensis whose water extracts seem to be a bit more potent at low dose. The analgesic
potencies of both extracts of all the four plants were shown to be less than those of the
standard analgesics. Of all the extracts, the ethanol extract of O. lamiifolium was found to be
the most potent, while its water extract was the least. Acetic acid induced writhing was
relieved with medium dose of both extracts in most cases and with low dose in few. Hundred
percent relief was achieved with both standard analgesics at a very low dose.
Conclusion: The present study show that all the extracts of all the plant materials have got
both inhibiting and relieving effects of pain.
Refbacks
- There are currently no refbacks.
