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DIAGNOSTIC POTENTIAL OF SERUM VITAMIN E TOCOPHEROL AND CHOLESTEROL LEVELS IN CHILDREN WITH PROTEIN ENERGY MALNUTRITION IN WESTERN KENYA
Abstract
ABSTRACT
Objective: To determine the levels and diagnostic potential of vitamin E (a-tocopherol) in
protein energy malnutrition (PEM) in western Kenya.
Design: Passive Hospital based study conducted on inpatients and outpatients.
Setting: Webuye sub-District and Moi Teaching and referral Hospitals, Western Kenya.
Subjects and Methods: Serum levels for vitamin E and cholesterol concentrations in children
< 5 years of age (n=56) admitted to Webuye District Hospital, Bungoma, Western Kenya and
some (n=3) admitted to Moi teaching and referral Hospital, Eldoret Kenya suffering from
Kwashiorkor, Marasmus or PEM and malaria plus there controls, for a period of one year
(January- December, 2001) were examined. High Performance Liquid Chromatography
(HPLC) and Spectrophotometry were used for the analysis.
Results: The serum vitamin E levels were higher in Kwashiorkor (0.078 mg/ml, SD 0.034)
than marasmus (0.075 mg/ml; SD 0.069) and controls (0.057 mg/ml; SD 0.022). The mean
serum cholesterol levels were higher in marasmus (204.6 mg/dl; SD 104.8) than Kwashiorkor
(186.0 mg/dl; SD 119.3) and controls (154.3; SD 33.3). There was a significant correlation in
vitamin E concentrations between Kwashiorkor and controls only at P< 0.01 as compared to
Marasmus and Marasmic/Kwashiorkor. Vitamin E levels did not show significant correlation
to cholesterol in malnourished children from Webuye, Bungoma in western Kenya at
P< 0.01.
Conclusion: Vitamin E could be a useful diagnostic tool for PEM in this area.
Objective: To determine the levels and diagnostic potential of vitamin E (a-tocopherol) in
protein energy malnutrition (PEM) in western Kenya.
Design: Passive Hospital based study conducted on inpatients and outpatients.
Setting: Webuye sub-District and Moi Teaching and referral Hospitals, Western Kenya.
Subjects and Methods: Serum levels for vitamin E and cholesterol concentrations in children
< 5 years of age (n=56) admitted to Webuye District Hospital, Bungoma, Western Kenya and
some (n=3) admitted to Moi teaching and referral Hospital, Eldoret Kenya suffering from
Kwashiorkor, Marasmus or PEM and malaria plus there controls, for a period of one year
(January- December, 2001) were examined. High Performance Liquid Chromatography
(HPLC) and Spectrophotometry were used for the analysis.
Results: The serum vitamin E levels were higher in Kwashiorkor (0.078 mg/ml, SD 0.034)
than marasmus (0.075 mg/ml; SD 0.069) and controls (0.057 mg/ml; SD 0.022). The mean
serum cholesterol levels were higher in marasmus (204.6 mg/dl; SD 104.8) than Kwashiorkor
(186.0 mg/dl; SD 119.3) and controls (154.3; SD 33.3). There was a significant correlation in
vitamin E concentrations between Kwashiorkor and controls only at P< 0.01 as compared to
Marasmus and Marasmic/Kwashiorkor. Vitamin E levels did not show significant correlation
to cholesterol in malnourished children from Webuye, Bungoma in western Kenya at
P< 0.01.
Conclusion: Vitamin E could be a useful diagnostic tool for PEM in this area.
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