INDUCTION OF LABOUR USING LOW AND HIGH DOSE REGIMENS OF PROSTAGLANDIN E2 VAGINAL TABLETS

Abstract

ABSTRACT
Objective: To compare the efficacy of low dose prostaglandin E2 vaginal tablets with
that of high dose in induction of labour.
Design: A retrospective study.
Setting: Abha Maternity Hospital, a teaching hospital in the southern region of Saudia
Arabia.
Patients: The outcome of induction of labour in 73 women induced with 1.5 mg
prostaglandin E2 vaginal tablets was compared with those in 168 women induced with
3 mg vaginal tablets.
Results: There were no statistical significant differences in the success rate, inductiondelivery
interval, caesarean section rate and Apgar scores between the two groups. There
were two incidences of uterine hyperstimulation and two of uterine rupture in the high
dose group. These were not statistically significant. Logistic regression analysis showed
that the success rate of induction of labour was dependent only on maternal age
(P=0.0025) and Bishop score (P=0.0403) and not on parity, gestational age, birthweight
or dose of prostaglandin.
Conclusion: The low dose regimen of 1.5 mg is as efficacious as the high dose regimen
of 3mg. prostaglandin E2 vaginal tablets in inducing labour. This implies that using
the low dose regimen reduces the cost of induction of labour effectively. Larger
prospective randomized studies are needed to confirm this finding.