EFFECTS OF HYPOKINESIA ON CYCLIC NUCLEOTIDES AND HORMONAL REGULATION OF CALCIUM METABOLISM IN RATS

Abstract

Objective: To study the dynamic of changes in the level of parathyroid hormone (PTH),
calcitonin (CT), cyclic nucleotides (cAMP, cGMP) and calcium in the blood of rats, while in
urine - phosphate, calcium and cyclic nucleotides
Design: Laboratory based experiment.
Setting: Laboratory in the Department of Biochemistry, Faculty of Medicine, University of
Nairobi, Nairobi, Kenya and in the Department of Biochemistry, Kharkov State University,
Ukrain Republic.
Results: Correlation between the changes in the parameters of study was shown. This supports
the theory about the relationship between branches of hormonal systems (cyclic nucleotides -
calcium), which perform the central role in the regulation of homeostasis. The results show that
daily excretion of calcium and phosphate is age dependent in rats during the pathogenesis of
hypokinesia: the values are higher in control groups. Changes in calcium in the blood and
phosphaturia in the experimental animals of all ages were attributed to changes in the intensive
re-absorption process within the bones during the readaptation period of hypokinesia.
Conclusion: Old rats have a higher ability to adaptation than younger experimental
counterparts during hypokinesia.