Antiulcerogenic activity of husk extract of Zea mays
Abstract
Background: Zea mays husk is used in Ibibio traditional medicine for the treatment of various ailments including diabetes mellitus, malaria and ulcer.
Objective: To investigate the antiulcerogenic potential of husk extract of Zea mays.
Methods: Ethanol husk extract of Zea mays (187-784 mg/kg) was evaluated for antiulcerogenic activity against indomethacin, ethanol and histamine-induced ulcers in rats.
Results: The husk extract was found to significantly (p<0.05 -0.001) inhibit ulcers induced by indomethacin, ethanol and histamine in a dose-dependent fashion.
Conclusion: These results suggest that the husk extract of Zea mays possess antiulcerogenic potentials which are due to the activities of the phytochemical constituents.
Keywords: Zea mays, husk, antiulcer, gastrointestinal system.
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