Antiulcerogenic activity of husk extract of Zea mays

Jude E Okokon, Jackson Obot, Louis U Amazu


Background: Zea mays husk is used in Ibibio traditional medicine for the treatment of various ailments including diabetes mellitus, malaria and ulcer.

Objective: To investigate the antiulcerogenic potential of husk extract of Zea mays.

Methods: Ethanol husk extract of Zea mays (187-784 mg/kg) was evaluated for antiulcerogenic activity against indomethacin, ethanol and histamine-induced ulcers in rats.

Results: The husk extract was found to significantly (p<0.05 -0.001) inhibit ulcers induced by indomethacin, ethanol and histamine in a dose-dependent fashion.

Conclusion: These results suggest that the husk extract of Zea mays possess antiulcerogenic potentials which are due to the activities of the phytochemical constituents.

Keywords: Zea mays, husk, antiulcer, gastrointestinal system.


Abo KA, Fred-Jaiyesimi AA, Jaiyesimi AEA (2008). Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria. J Ethnopharmacol . 115: 67-71.

Agwu CN, Okunji CO (1986). Gastrointestinal studies of Pyrenacantha staudtii leaf extracts. J. Ethnopharmacol. 15: 45 – 55.

Alphin RS, Ward JW (1967). Action of hexopyrronium bromide on gastric secretion in dogs and on gastric secretion and ulceration in rats. Archives Internationales de Pharmacodynamie et de Therapie 270: 128 -140.

Bhargava KP, Gupta MB, Tangri KK (1973).Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone. Eur. J.Pharmacol. 22:191 – 195.

Borrelli F, Izzo AA (2000). The plant kingdom as source of anti-ulcer remedies. Phytother Res. 14: 581 – 591.

Cho CH, Pfeiffer CJ (1981). Gastrointestinal ulceration in the guinea pigs in response to dimaprit, histamine and H1 and H2 blocking agents. Digestive Dis. Sci. 26:306 – 311.

Di Carlo G, Mascolo N, Izzo AA, Capasso F (1999). Flavonoids: old and new aspects of a class of a natural therapeutic drug. Life Sci. 64: 337 – 353.

Dong J, Cai L, Zhu X, Huang X, Yin T, Fang H and Ding Z (2014). Antioxidant activities and phenolic compounds of cornhusk, corncob and Stigma Maydis. J. Braz. Chem. Soc. 25: 1956-1964.

Evbuonwa MT, Bolarinwa AF (1990). Effect of diet on indomethacin-induced peptic ulceration in pregnant rats. Nig. J. Physiol. Sci. 6:189 – 191.

Foster S, Duke JA. (1990). Field Guide 10 Medical Plants: Eastern and Central North America. Houghton MifAin, Boston, 1990.

Gill LS (1992). Ethnomedical Uses of Plants in Nigeria. Uniben Press, Benin, Nigeria, p. 249.

Hayllar J, Bjarnason I (1995). NSAIDS, COX-2 inhibitor and the gut. Lancet. 346:521 - 522.

Hiruma-Lima CA, Calvo TR, Rodriguez CM, Andrade FDP, Vilegas W, Brito ARM (2006). Antiulcerogenic activity of Alchornea castaneaefolia effects on somatostatin, gastrin and prostaglandin. J. Ethnopharmacol. 104: 215 – 224.

Jadhav SM (2016). Protective effect of Zea mays (Poaceae) on experimentally induced gastric ulcer in Rats. Imperial J. Interdisciplinary Res. 2: 593-600.

Lewis DA, Hanson D (1991). Anti-ulcer drugs of plants origin. Progr. Med. Chem. 28:208 – 210.

Li CY, Kim HW, Won SR, Min HK, Park KJ, Park JY, Ahn MS, Rhee HI (2008). Corn husk as a potential source of anthocyanins. J Agr Food Chem. 56: 11413 -11416.

Maity S,Vedasiromoni JR, Ganguly DK (1995). Antiulcer effect of the hot water extract of black tea (Camellia sinensis). J. Ethnopharmacol. 46: 167 – 174.

Nwafor PA, Effraim KD, Jacks TW (1996). Gastroprotective effects of aqueous extracts of Khaya senegalensis bark on indomethacin – induced ulceration in rats. West Afr. J. Pharmacol. Drug Res 12:46 – 50.

Nwafor PA, Okwuasaba FK, Binda LG (2000). Antidiarrhoeal and antiulcerogenic effects of methanolic extracts of Asparagus pubescens root in rats. J. Ethnopharmacol. 72:421 – 427.

Ogawa K, Takeuchi M, Nakamura N (2005). Immunological effects of partially hydrolysed arabinoxylan from corn husk in mice. Biosci. Biotech. Biochem. 69:19-25.

Okokon JE, Antia BS, Mohanakrishnan D, Sahal D (2017a). Antimalarial and antiplasmodial activities of Zea mays husk. Pharm. Biol. 55: 1394 -1400.

Okokon JE, Nyong ME, Essien GE, Nyong E (2017b). Hepatoprotective activity of husk extract and fractions of Zea mays against alloxan induced oxidative stress in diabetic rats. Int. J. Herbal Med. 5:43-50.

Okokon JE, Nyong ME, Essien GE, Nyong E (2017c). Nephroprotective activity of husk extract and fractions of Zea mays against alloxan induced oxidative stress in diabetic rats. J. Basic Pharmacol. Toxicol. 1:1-10.

Okokon JE, Nelson E, Sunday M (2016). Antidepressant activity of ethanol Husk extract of Zea mays. Adv Herbal Med. 2: 22 -28.

Owoyele BV, Negedu MN, Olaniran SO, Onasanwo SA, Oguntoye SO, Sanya JO, Oyeleke SA, Ibidapo AJ, Soladoyel AO (2010). Analgesic and anti-inflammatory effects of aqueous extract of Zea mays husk in male Wistar rats. J. Med. Food 13:343-347.

Pihan G, Regillo, C, Szabo S (1987). Free radicals and lipid peroxidation in ethanol or aspirin – induced gastric mucosa injury. Dig. Dis. Sci. 32: 1395 – 1401.

Rainsford KD (1987). The effects of 5- lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal anti-inflammatory drugs in mice. Agents Actions. 21:316 – 319.

Salim AS (1990). Removing oxygen derived free radicals stimulates healing of ethanol- induced erosive gastritis in the rats. Digestion. 47: 24 – 28.

Simmonds NW (1979). Evolution of Crop Plants. Longman. London. pp. 128-129.

Whittle BJR, Oren-Wolman N, Guth PH (1985). Gastric vasoconstrictor actions of leukotriene C4 and PGF2α and thromboxane mimetic (U-4669) on rats submucosal microcirculation in vivo. Am. J. Physiol. 248: G580 – G586

Zaidi SH, Mukerji B (1958). Experimental peptic ulceration. Part 1. The significance of mucus barrier. Ind. J. Med. Res. 46:27 – 37.

Zayachkivska OS, Konturek SJ, Drozdowicz D, Konturek PC, Brzozowski T, Ghegotsky MR (2005). Gastroprotective effects of flavonoids in plants extracts. J. Physiol. Pharmacol. 56: 216 - 231.

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