Dose-dependent myocardial toxicity of Mangifera indica during diarrhoea treatment

Abstract

Background: The use of alternative medicine is on the rise worldwide. Mangifera indica kernel has been used as a diarrhoea remedy. Studies have demonstrated its mechanism of action to be via the sympathomimetic pathway. Possible adverse effects on the cardiovascular system were however unknown.

Objective: The current study aimed to investigate the in-vitro effects of Mangifera indica kernel extract (MIE) on myocardial activity.

Methodology: The dose-related effects of MIE were tested on isolated rabbit hearts, and the mechanism of action verified. This was then compared against its efficacy on the jejunum, and the likelihood of myocardial toxicity investigated.

Results: MIE significantly enhanced myocardial contractility with no effect on the frequency. However, the doses required for this effect were much higher than those that would be required to treat diarrhoea.

Discussion: The use of MIE as a diarrhoea remedy is probably safe on the cardiovascular system provided the dose is maintained within an anti-diarrhoeal therapeutic window.

Key words: Diarrhoea, adverse effects, mango kernel, myocardial activity.