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EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON HYPERTENSION CONTROLUSING ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND THIAZIDE DIURETICS
Abstract
Objectives: To determine the impact of three non-steroidal anti-inflammatory drugs on the
efficacy of two anti-hypertensive drugs.
Design: Fifteen women with arthritis and hypertension who were receiving lisinopril and
HCT, and administered sequentially in random order ibuprofen, sulindac, and diclofenac
for one month each, with an intervening two-week washout period between each treatment
period. During the washout period, subjects received paracetamol.
Setting: Hypertension Clinic, Medical Centre, Harare, Zimbabwe.
Subjects: Fifteen female hypertensive women with documented arthritis.
Main outcome measures: Blood pressure at the end of two weeks of paracetamol was
compared with blood pressure after one month of treatment with each of the NSAID.
Results: Mean blood pressure was unchanged before and after all NSAIDs: 108 + 7 versus
107 f 9 for diclofenac, 108 It 9 versus 108 f 9 for sulindac, and 108 + 8 versus 107 f 9 for
ibuprofen. The 24 hour urinary sodium excretion was not significantly different.
Conclusion: The three NSAIDs investigated did not neutralise the antihypertensive effect of
the combination of lisinopril and HCT, and hence the blood pressure lowering action of the
combination may not be prostaglandin dependent.
efficacy of two anti-hypertensive drugs.
Design: Fifteen women with arthritis and hypertension who were receiving lisinopril and
HCT, and administered sequentially in random order ibuprofen, sulindac, and diclofenac
for one month each, with an intervening two-week washout period between each treatment
period. During the washout period, subjects received paracetamol.
Setting: Hypertension Clinic, Medical Centre, Harare, Zimbabwe.
Subjects: Fifteen female hypertensive women with documented arthritis.
Main outcome measures: Blood pressure at the end of two weeks of paracetamol was
compared with blood pressure after one month of treatment with each of the NSAID.
Results: Mean blood pressure was unchanged before and after all NSAIDs: 108 + 7 versus
107 f 9 for diclofenac, 108 It 9 versus 108 f 9 for sulindac, and 108 + 8 versus 107 f 9 for
ibuprofen. The 24 hour urinary sodium excretion was not significantly different.
Conclusion: The three NSAIDs investigated did not neutralise the antihypertensive effect of
the combination of lisinopril and HCT, and hence the blood pressure lowering action of the
combination may not be prostaglandin dependent.
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