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ENTEROTOXIGENICITY AND DRUG SENSITIVITY OF STAPHYLOCOCCI FROM CHILDREN AGED FIVE YEARS AND BELOW WITH SPORADIC DIARRHOEA
Abstract
ABSTRACT
Objective: To investigate the incidence of enterotoxigenic strains of staphylococci in
children aged five years and below suffering from sporadic diarrhoea and their antibiotic
susceptibility pattern.
Design: Collection of stool samples from children with sporadic diarrhoea and laboratory
based microbiological analysis.
Setting: Microbiology Research Laboratory, Department of Veterinary Microbiology and
Parasitology, University of Ibadan, Ibadan, Nigeria.
Results: Out of one thousand seven hundred and sixty one diarhoeic faecal specimens
collected, one hundred and seven strains of staphylococci were isolated as pure culture.
Seventy two of these 107 staphylococci were coagulase positive S. aureus, 33 strains
were S. epidermidis and two strains were S. saprophyticus. Sixty one (84.7%) of 72 isolates
of S. aureus produced enterotoxins. Staphylococcal enterotoxins A was produced singly
by 37(60.7%) of the toxigenic strain, while 12(19.7%) produced enterotoxin D alone.
Two strains produced both enterotoxins A and C, six strains produced both enterotoxins
A and D, one strain produced enterotoxins A, C and D while two strains produced
enterotoxins A, B, and D. Most strains were resistant to pennicilin, with minimum
inhibitory concentrations (MIC) within the range of 1-16m g/ml.
Conclusion: Enterotoxigenic strains of S. aureus were recovered from children aged five
years and below suffering from sporadic diarhoea. The incidence rate was 3.5% of the
samples investigated. Results of their antibiogram revealed that chloramphenicol,
gentamicin, cephalothin and clindamycin would be appropriate for treatment of such
diarrhoea after the clinical value of the antibiotics in young children has been evaluated.
Objective: To investigate the incidence of enterotoxigenic strains of staphylococci in
children aged five years and below suffering from sporadic diarrhoea and their antibiotic
susceptibility pattern.
Design: Collection of stool samples from children with sporadic diarrhoea and laboratory
based microbiological analysis.
Setting: Microbiology Research Laboratory, Department of Veterinary Microbiology and
Parasitology, University of Ibadan, Ibadan, Nigeria.
Results: Out of one thousand seven hundred and sixty one diarhoeic faecal specimens
collected, one hundred and seven strains of staphylococci were isolated as pure culture.
Seventy two of these 107 staphylococci were coagulase positive S. aureus, 33 strains
were S. epidermidis and two strains were S. saprophyticus. Sixty one (84.7%) of 72 isolates
of S. aureus produced enterotoxins. Staphylococcal enterotoxins A was produced singly
by 37(60.7%) of the toxigenic strain, while 12(19.7%) produced enterotoxin D alone.
Two strains produced both enterotoxins A and C, six strains produced both enterotoxins
A and D, one strain produced enterotoxins A, C and D while two strains produced
enterotoxins A, B, and D. Most strains were resistant to pennicilin, with minimum
inhibitory concentrations (MIC) within the range of 1-16m g/ml.
Conclusion: Enterotoxigenic strains of S. aureus were recovered from children aged five
years and below suffering from sporadic diarhoea. The incidence rate was 3.5% of the
samples investigated. Results of their antibiogram revealed that chloramphenicol,
gentamicin, cephalothin and clindamycin would be appropriate for treatment of such
diarrhoea after the clinical value of the antibiotics in young children has been evaluated.
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