CORRELATION OF CD4 COUNTS AND CD4/CD8 RATIO WITH HIVINFECTION ASSOCIATED ORAL MANIFESTATIONS

Abstract

ABSTRACT
Background: The relationship between oral lesions arising from HIV infection and CD4/CD8 cell
ratios is of relevance in clinical assessment of immune suppression.
Objective: To correlate the prevalence of oral manifestations arising from HIV infection and the
levels of CD4/CD8 cell ratios.
Design: A cross-sectional study.
Setting: Kenyatta National Hospital, Nairobi, Kenya.
Subjects: Two hundred and seven HIV-infected patients in medical wards were recruited in the
study.
Results: Seventy eight (37.7%) were male and 129 (62.3%) female, with an age range of 18-73 years
(mean = 34.81 years). Oral manifestations encountered with highest prevalence in the oral cavity
included: hyperplastic candidosis (labial mucosa) 15%, erythematous candidosis (gingival) 5%,
angular cheilitis 32.4%, herpes simplex(corner of the mouth) 0.5%, persistent oral ulceration (labial
mucosa) 0.5%, Parotid enlargement 2% and Kaposis sarcoma (hard/soft palate) 2.9%.
Conclusion: The prevalence of oral manifestations was higher with low CD4 count <200 cell/mm3
and mean CD4/CD8<0.39(95%CI 0.32-0.48).