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SERUM ALBUMIN, CREATININE, URIC ACID AND HYPERTENSIVE DISORDERS OF PREGNANCY
Abstract
ABSTRACT
Background: Pre-eclampsia is a form of hypertensive disorder of pregnancy. It is a common
cause of both maternal and perinatal morbidity and mortality in both developed and
developing countries.
Objective: To evaluate the possibility of early prediction of hypertensive disorders of
pregnancy using single estimation of serum protein, creatinine and uric in serum samples of
healthy primigravidae with singleton pregnancy.
Setting: University College Hospital, Ibadan.
Subjects: Fifty nine normortensive primigravidae.
Methods: Fifty nine healthy normotensive primigravidae with singleton pregnancy who
booked for antenal care and delivered at the University College Hospital, Ibadan had single
estimations of their serum albumin, creatinine and uric acid levels at booking before the 20th
week of pregnancy. The women were followed up longitudinally throughout pregnancy.
Results: Pre-eclampsia occurred in five of the patients (21.7%), two had pregnancy induced
hypertension only (8.7%) while 16 remained normotensive (69.6%). The difference in the
mean serum concentration of uric acid (0.162± 0.02 mmol/L) and creatinine (93.70± 10.08
μmol/L) respectively were not statistically significant (p>0.05). However, the difference in the
mean serum albumin levels (4.06± 0.06 versus 3.71±0.33 gm/dl) was significantly higher in
the pre-eclampsia group (p<0.05). The predictive performance of these tests was generally
low whether alone or in combination.
Conclusion: Single estimation of serum uric acid and creatinine levels early in pregnancy are
of little value in the prediction of pre-eclampsia. A large study is recommended to properly
define the value of serum albumin levels in pregnancy in the prediction of pre-eclampsia in
the light of the findings of this study.
Background: Pre-eclampsia is a form of hypertensive disorder of pregnancy. It is a common
cause of both maternal and perinatal morbidity and mortality in both developed and
developing countries.
Objective: To evaluate the possibility of early prediction of hypertensive disorders of
pregnancy using single estimation of serum protein, creatinine and uric in serum samples of
healthy primigravidae with singleton pregnancy.
Setting: University College Hospital, Ibadan.
Subjects: Fifty nine normortensive primigravidae.
Methods: Fifty nine healthy normotensive primigravidae with singleton pregnancy who
booked for antenal care and delivered at the University College Hospital, Ibadan had single
estimations of their serum albumin, creatinine and uric acid levels at booking before the 20th
week of pregnancy. The women were followed up longitudinally throughout pregnancy.
Results: Pre-eclampsia occurred in five of the patients (21.7%), two had pregnancy induced
hypertension only (8.7%) while 16 remained normotensive (69.6%). The difference in the
mean serum concentration of uric acid (0.162± 0.02 mmol/L) and creatinine (93.70± 10.08
μmol/L) respectively were not statistically significant (p>0.05). However, the difference in the
mean serum albumin levels (4.06± 0.06 versus 3.71±0.33 gm/dl) was significantly higher in
the pre-eclampsia group (p<0.05). The predictive performance of these tests was generally
low whether alone or in combination.
Conclusion: Single estimation of serum uric acid and creatinine levels early in pregnancy are
of little value in the prediction of pre-eclampsia. A large study is recommended to properly
define the value of serum albumin levels in pregnancy in the prediction of pre-eclampsia in
the light of the findings of this study.
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