RISK FACTORS FOR PRETERM PREMATURE RUPTURE OF MEMBRANES AT MULAGO HOSPITAL, KAMPALA

Abstract

Objective: To evaluate the epidemiological risk factors in patients admitted at Mulago
Hospital with preterm premature rupture of the membranes from their socio-demographic
characteristics and reproductive history.
Design: Cross-sectional case control study.
Setting: Labour ward, Mulago Hospital, Kampala, Uganda.
Methods: Cases were enrolled at admission while controls were enrolled after a term delivery
not preceded by pre-mature rupture of the membrane (PROM). Controls were matched for
age range (age +2 years) and parity with the cases. A detailed history of socio-demographic
characteristics, past medical and surgical illness and past reproductive history were obtained
and data entered into a coded questionnaire. Endocervical swabs and amniotic fluid samples
were taken from the cases during labour. Validity was assessed using Chi-square with a pvalue
of less than 0.05 considered significant.
Results: Maternal socio-demographic characteristics were similar for cases and controls. A
history of hypertension, abortion, prior PROM, Caesarean section, cervical cerclage,
cervical incompetence or abnormal vaginal discharge were significant risk factors for
preterm PROM (p < 0.05).
Conclusion: There are factors by which mothers at risk of preterm PROM can be identified
before onset of rupture