Open Access
Subscription or Fee Access
GASTRO INTESTINAL HYPERPERMEABILITY: A REVIEW
Abstract
ABSTRACT
Objectives: To present a wide overview of the recent developments in the understanding of
the aetiopathogenesis of gastrointestinal hyperpermeability.
Data sources: Medline, from 1985, was sourced for relevant articles. Review articles were
included in order to minimise the number of references in the reference list.
Study selection: Results from experiments and observations on humans and other mammalian
species were studied.
Data synthesis: The major mechanisms elucidated in the aetiopathogenesis of the
gastrointestinal hyperpermeability were integrated and consolidated into a flow diagram
and the major factors responsible for normal permeability presented for comparison.
Conclusion: The occurrence of increased gastrointestinal hyperpermeability is probably
vastly underestimated. In addition to the hyperpermeability commonly associated with
chronic gastro intestinal disorders, an increase in gastrointestinal permeability may occur in
any condition of metabolic depletion, enterocyte ATP-depletion, stimulation of gastrointestinal
pro-inflammatory cytokine production and disturbances of the normal gastrointestinal flora
as with prolonged use of antibiotics.
Objectives: To present a wide overview of the recent developments in the understanding of
the aetiopathogenesis of gastrointestinal hyperpermeability.
Data sources: Medline, from 1985, was sourced for relevant articles. Review articles were
included in order to minimise the number of references in the reference list.
Study selection: Results from experiments and observations on humans and other mammalian
species were studied.
Data synthesis: The major mechanisms elucidated in the aetiopathogenesis of the
gastrointestinal hyperpermeability were integrated and consolidated into a flow diagram
and the major factors responsible for normal permeability presented for comparison.
Conclusion: The occurrence of increased gastrointestinal hyperpermeability is probably
vastly underestimated. In addition to the hyperpermeability commonly associated with
chronic gastro intestinal disorders, an increase in gastrointestinal permeability may occur in
any condition of metabolic depletion, enterocyte ATP-depletion, stimulation of gastrointestinal
pro-inflammatory cytokine production and disturbances of the normal gastrointestinal flora
as with prolonged use of antibiotics.
Refbacks
- There are currently no refbacks.
