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METABOLIC CONTROL OF TYPE-2 DIABETIC PATIENTS COMMONLY TREATED WITH SULPHONYLUREAS IN A DEVELOPING COUNTRY
Abstract
ABSTRACT
Background: Previous reports suggest that currently available drugs used in the treatment
of type 2 diabetes do not sustain glycaemic control.
Objective: To assess metabolic control in type 2 diabetic patients predominantly treated with
sulphonylurea drugs at primary care clinics in a developing country.
Design: Descriptive.
Setting: Two primary care clinics in Trinidad, West Indies.
Subjects: One hundred and seventy nine (117 females and 62 males), randomly selected, type
2 diabetic patients.
Protocol: Body weight, height, blood pressure (BP), waist and hip circumferences were
measured and fasting blood samples taken for glycated haemoglobin (HbAlc, glucose, insulin
and lipids determinations. Fasting insulin and glucose concentrations were used to assess
insulin resistance and sensitivity (%S) using Homeostasis model assessment (HOMA)
method.
Results: Of the 179 patients studied, 87% of male and 92% of female patients were treated
with sulphonylurea drugs whereas 13% and 9% of male and female patients respectively
were managed on diet and/or exercise. Female patients had significantly higher prevalence
of obesity than males, and despite similar fasting glucose and HbAlc, levels, the females and
patients of East Indian ethnic group had significantly higher prevalence rates of insulin
resistance, hypercholesterolaemia, hypertriglyceridaemia and reduced HDL-cholesterol
than the males and patients of African origin respectively.
Conclusion: Consistent with previous reports, the results showed indications of poor
metabolic control among the patients particularly females and patients of East Indian ethnic
group.
Background: Previous reports suggest that currently available drugs used in the treatment
of type 2 diabetes do not sustain glycaemic control.
Objective: To assess metabolic control in type 2 diabetic patients predominantly treated with
sulphonylurea drugs at primary care clinics in a developing country.
Design: Descriptive.
Setting: Two primary care clinics in Trinidad, West Indies.
Subjects: One hundred and seventy nine (117 females and 62 males), randomly selected, type
2 diabetic patients.
Protocol: Body weight, height, blood pressure (BP), waist and hip circumferences were
measured and fasting blood samples taken for glycated haemoglobin (HbAlc, glucose, insulin
and lipids determinations. Fasting insulin and glucose concentrations were used to assess
insulin resistance and sensitivity (%S) using Homeostasis model assessment (HOMA)
method.
Results: Of the 179 patients studied, 87% of male and 92% of female patients were treated
with sulphonylurea drugs whereas 13% and 9% of male and female patients respectively
were managed on diet and/or exercise. Female patients had significantly higher prevalence
of obesity than males, and despite similar fasting glucose and HbAlc, levels, the females and
patients of East Indian ethnic group had significantly higher prevalence rates of insulin
resistance, hypercholesterolaemia, hypertriglyceridaemia and reduced HDL-cholesterol
than the males and patients of African origin respectively.
Conclusion: Consistent with previous reports, the results showed indications of poor
metabolic control among the patients particularly females and patients of East Indian ethnic
group.
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