

ANTIMICROBIAL SUSCEPTIBILITY IN COMMUNITY-ACQUIRED BACTERIAL PNEUMONIA IN ADULTS
Abstract
ABSTRACT
Objectives: To determine the antimicrobial susceptibility patterns of Streptococcus pneumoniae
and Haemophilus influenzae, two bacterial pathogens commonly associated with communityacquired
pneumonia.
Design: Cross-sectional study.
Setting: Bacterial isolates were obtained from adults suspected to have community-acquired
pneumonia and who sought treatment at two city council clinics in Nairobi, Kenya.
Susceptibility to antimicrobial agents was performed using a microdilution broth method,
according to the criteria set by the National Committee for Clinical Laboratory Standards.
Results: A total of 277 S. pneumoniae and 58 H. influenzae were obtained from 536 adults
examined in the period January 1998 to December 1999. Of the 277 S. pneumoniae, only
56.7% were susceptible to penicillin and 7.6% of strains were resistant to two or more
antimicrobial agents. Of the 58 H.influenzae strains, 91.4% were sensitive to ampicillin, with
6.8% resistant to two or more antimicrobial agents. 8.6% were ß-lactamase producers and
accounted for the entire ampicillin-resistant population.
Conclusion: The prevalence of resistance to penicillin and other commonly used antibiotics
among pneumococci is high and the large number of multi-resistant strains among H.
influenzae is a cause for concern. The prudent use of antibiotics in treatment of pneumonia
and other infections should be advocated to minimise spread of resistance.
Objectives: To determine the antimicrobial susceptibility patterns of Streptococcus pneumoniae
and Haemophilus influenzae, two bacterial pathogens commonly associated with communityacquired
pneumonia.
Design: Cross-sectional study.
Setting: Bacterial isolates were obtained from adults suspected to have community-acquired
pneumonia and who sought treatment at two city council clinics in Nairobi, Kenya.
Susceptibility to antimicrobial agents was performed using a microdilution broth method,
according to the criteria set by the National Committee for Clinical Laboratory Standards.
Results: A total of 277 S. pneumoniae and 58 H. influenzae were obtained from 536 adults
examined in the period January 1998 to December 1999. Of the 277 S. pneumoniae, only
56.7% were susceptible to penicillin and 7.6% of strains were resistant to two or more
antimicrobial agents. Of the 58 H.influenzae strains, 91.4% were sensitive to ampicillin, with
6.8% resistant to two or more antimicrobial agents. 8.6% were ß-lactamase producers and
accounted for the entire ampicillin-resistant population.
Conclusion: The prevalence of resistance to penicillin and other commonly used antibiotics
among pneumococci is high and the large number of multi-resistant strains among H.
influenzae is a cause for concern. The prudent use of antibiotics in treatment of pneumonia
and other infections should be advocated to minimise spread of resistance.

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