OUTCOME AND HAEMATO-TOXICITY OF TWO CHEMOTHERAPY REGIMENS FOR CHILDHOOD NON-HODGKIN’S LYMPHOMA IN A KENYAN HOSPITAL

Abstract

Background: Effectiveness and toxicity of childhood cancer treatments have never beenevaluated in Kenya since introduction of structured care in the early seventies.

Objective:To evaluate effectiveness and toxicity of two treatment protocols for Non-Hodgkin’s lymphoma (NHL).

Design: Historical cohort study using medical records.

Setting: Kenyatta National Hospital, a tertiary care and medical teaching hospital.

Subjects: Children ≤ 15 years with diagnosis of non-Hodgkin’s Lymphoma.

Main outcome measures: Primary outcomes were median survival, event free survivaland toxicity.Results: Out of 101 records, only 26 (25.7%) met inclusion criteria. Baseline characteristicswere similar in the two treatment arms. Median survival was 0.75 months (95%CI=0.54-0.96) and 1.0 months (95% CI=0.29-1.71) for short and long arm groups. There was nodifference in event free survival and haematological toxicity.

Conclusion: No clear difference in effectiveness and toxicity between the intensiveshortand the less aggressive long course chemotherapy regimens was evident. Thoughlack of difference may be attributed to the small sample size, suboptimal supportivecare for intensive treatment would increase risk of toxic deaths. As the short courseprotocol did not demonstrate obvious deterioration of median and event free survival,a strong case may be made for a randomised clinical trial within a context of improvedsupportive care.