Safety, anti-inflammatory and analgesic assessments of methanolic extract of Musa paradisiaca peel in Sprague Dawley rats
Abstract
Background: Musa paradisiaca peel is used in folklore for the treatment of inflammation and pains without any scientific evidence.
Objective: The present study, therefore, evaluated the safety, anti-inflammatory and analgesic effects of the methanolic extract of M. paradisiaca peel.
Methods: The methanolic extract of M. paradisiaca was administered orally in three different doses; 100, 200 and 400 mg/kg to Sprague Dawley rats. The anti-inflammatory effect of M. paradisiaca peel was tested in egg albumin-induced paw edema and compared to ibuprofen (25 mg/kg). The analgesic effect was evaluated using formalin-induced paw licking and acetic acid-induced writhing and compared to indomethacin (10 mg/kg). Also, after 21 days of extract administration rats were sacrificed serum was extracted from blood and evaluated for liver, renal function indices and lipid profile. Kidney and liver were excised and weighed.
Results: The methanolic extract of M. paradisiaca produced analgesia and decreased inflammation significantly (p<0.05) and in a dose dependent manner. The anti-inflammatory and analgesic effects were significant (p<0.05) at 400 mg/kg of M. paradisiaca when compared to ibuprofen (25mg/kg) and indomethacin (10mg/kg) respectively. Furthermore, M. paradisiaca did not produce significant (p>0.05) effects on organ weight, serum alkaline phosphatase, aminotransferases, conjugated bilirubin, total bilirubin, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, glucose, creatinine, urea, uric acid, total protein, albumin, and serum electrolytes when compared to control.
Conclusion: This study observed that the methanolic extract of M. paradisiaca peel has anti-inflammatory and analgesic effects and may be safe with use.
Key words: Musa paradisiaca, anti-inflammatory, analgesic, toxicity, rats
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