Antidepressant activity of ethanol leaf extract of Panicum maximum
Abstract
Background: Panicum maximum is used in Ibibio ethnomedicine for the treatment of various diseases including central nervous system disorders.
Objective: To investigate the in vivo antidepressant activity of Panicum maximum.
Methods: The ethanol leaf extract of Panicum maximum (48 -144 mg/kg) was investigated for antidepressant activity in in Swiss albino mice using open field, force swimming and tail suspension tests.
Results: The extract was found to significantly (p<0.05-0.01) increase the frequency of line crossing, rearing and walling activities of mice in open field test. The extract also decreased significantly (p<0.05-0.001) duration of immobility time of mice in force swimming and tail suspension tests.
Conclusion: The leaf extract of P. maximum has antidepressant activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.
Keywords: Panicum maximum, antidepressant, CNS stimulant
References
Antia BS, Okokon JE, Umoh E E, Udobang JA (2010). Antidiabetic activity of Panicum maximum. Int. J. Drug Dev. Res. 2: 488 - 492.
Archer J (1973). Tests for emotionality in mices and mice: a review. Anim. Behav. 21:205 - 235.
Dalziel JM (1956). Useful Plants of West Tropical Africa, Crown Agents for Overseas Government: London.
Daval J, Nehlig A, Nicholas F. (1991). Physiological & Pharmacological properties of adenosine: Therapeutic implications. Life Sci. 49:1435 - 53.
Detke M, Rickels M, Lucki J (1995). Active behaviours in the rats forced swimming test differentially activated by serotonergic and noradrenergic antidepressants. Psychopharmacology 121: 66 – 72.
Dhingra D, Sharma A (2005). Evaluation of antidepressant-like activity of glycyrrhizin in mice. Ind. J. Pharmacol. 37:390 - 394.
Doss A, Parivuguna V, Vijayasanthi M and Sruthi S (2011a). Antibacterial evaluation and phytochemical analysis of certain medicinal plants, Western Ghats, Coimbatore. J. Res. Biol. 1: 24-29.
Doss A, Vijayasanthi M, Parivuguna V Anand SP (2011b). Evaluation of antibacterial properties of ethanol and flavonoids from Mimosa pudica linn. and Panicum maximum Jacq. Plant Sci. Feed 1: 39 – 44.
Gothandam KM, Aishwarya R. and Karthikeyan S (2010). Preliminary screening of antimicrobial properties of few medicinal plants. J. Phytol. 2: 01 – 06.
Habtemariam S, Gray AI, Waterman PG (1993). A new antibacterial sesquiterpenes from Premna aligotricha. J. Nat. Prod. 56: 3864 - 74.
Hemby SE, Lucki I, Gatto G, Singh A, Thornley C, Matasi J (1997). Potential antidepressant effects of novel tropane compounds, selective for serotonin and dopamine transporters. J. Pharmacol. Expl. Ther. 282: 727 -733.
Hossain MM, Biva IJ, Jahangir R,Vhuiyan MMI (2009). CNS depressant and analgesic activity of Aphanamixis polystachya (wall.) parker leaf extract in mice. Afr. J. Pharm. Pharmacol. 3: 282 - 286.
Kanife UC, Odesanmi OS, Doherty VF (2012). Phytochemical composition and antifungal properties of leaf, stem and florets of Panicum maximum Jacq. (Poaceae). Int. J. Biol. 4: 64 – 96.
Kolawole OT, Makinde JM, Olajide OA (2007). Central nervous system depressant activity of Russelia equisetiformis. Nig. J. Physiol. Sci. 22: 59-63.
Lowe J. (1989). The Flora of Nigeria Grasses (2nd Edition) Ibadan University Press. Ibadan, Nigeria, 1989.
Lu DY, Tsao YY, Leung YM, Su KP. (2010). Docosahexaenoic acid suppresses neuro-inflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for ω-3 fatty acids. Neuropsychopharmacol. 35:2238-2248.
Lucki I (1997). The forced swimming test as a model for core and component behavioural effects of antidepressant drugs. Behavioural Pharmacol. 8: 523 - 532.
Naveen S, Siddalingaswamy M, Singsit D, Khanum F (2013). Anti-depressive effect of polyphenols and Omega-3 fatty acid from pome granate peel and flax seed in mice exposed to chronic mild stress. Pschiatry and Neurosci. 67: 501-508.
Neering IR, Me Burney RM (1984). Role for microsomal calcium storage in mam-malian neurons? Nature (London) 309:158 -160.
Noldner M, Schotz K (2002). Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Med. 68: 577 - 580.
Nyeem MAB, Alam MA, Awal MA, Mostofa M, Uddin SJ, Islam N, Rouf R.(2006). CNS depressant effect of the crude ethanolic extract of the flowering tops of Rosa damascena. Iranian J. Pharmacol. Ther. 5:171-174.
Okokon JE, Okokon PJ, Dar A., Choudhary MI. Kasif M, Asif M, Mudassir A, Izhar A (2014). Immunomodulatory, anticancer and antileishmanial activities of Panicum maximum. Int. J. Phytother. 4: 87 -92.
Okokon JE, Nwafor PA (2010). Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus. Pak. J. Pharmaceut. Sci. 23: 383 - 390.
Okokon JE, Udoh AE, Udo NM, Frank SG (2011). Antiinflammatory and antipyretic activities of Panicum maximum. Afr. J. Biomed. Res. 14: 125 - 130.
Okokon JE., Nwafor P.A., Andrew U (2012). Antiplasmodial and analgesic activities of ethanolic leaf extract of Panicum maximum. Asian Pac. J. Trop. Med. 4: 442 – 446.
Ozturk Y, Aydini S, Beis R, Baser KHC, Berberoglu H.(1996). Effect of Hypericum pericum L. and Hypericum calycinum l. extracts on the central nervous system in mice, Phytomed. 3: 139 - 146.
Porsolt RD, Bertin A, Jalfre M (1977). Behavioural despair in mice: a primary screening test for antidepressants. Arch. Internationales de Pharmacodynamie et de Therapie 229: 327 - 336.
Porsolt RD, Anton G, Deniel M, Jalfre M (1978). Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47: 379 - 391.
Porter RJ, Meldrum BS. (2001). Antiseizure drugs. In: Katzung BG. (Ed), Basic and Clinical Pharmacology. 8th ed. Lange Medical Books/McGraw-hill, New York. pp.403 – 417.
Raquibul Hasan SM, Hossain MM, Akter R, Jamila M, Mazumder EHM, Rahman S (2009). Sedative and anxiolytic effects of different fractions of the Commelina benghalensis Linn. Drug Discov Ther. 3: 221 - 227
Steru L, Chermat R, Thierry B, Simon P (1985). The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacol. 85: 367 - 370.
Su KP (2008). Mind-body interface: the role of n-3 fatty acids in psychoneuroimmunology, somatic presentation, and medical illness comorbidity of depression. Asia Pac. J. Clin. Nutr. 17 Suppl 1:151-157.
Su KP (2012). Inflammation in psychopathology of depression: clinical, biological, and therapeutic implications. Bio-Medicine 2:68-74.
Su K, Matsuoka Y, Pae C (2015). Omega-3 polyunsaturated fatty acids in prevention of mood and anxiety disorders. Clin. Psychopharmacol. Neurosci. 13: 129-137.
Tutka P, Turski WA, Kleinrok Z (1996). Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice. J, Neural Transm. 103:307-314.
Van Oudtshoorn FP (1999). Guide to Grasses of South Africa. Briza Publications, Cape Town.
Willner P (1984). The validity of animal models of depression. Psychopharmacol. 83: 1–16.
Yadav A V, Kawale LA, Nade VS (2008). Effect of Morus alba L leaves on anxiety in mice. Ind. J. Pharmacol. 40: 32-36.
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