Anti-inflammatory and analgesic effects of Lonchocarpus cyanescens root in mice - Supporting Information

Abstract

Background: The root of Lonchocarpus cyanescens is one common remedy of the Ibibios of Akwa Ibom State, Nigeria for the treatment of pain and inflammatory disorders.

Objective: To study and validate the anti-inflammatory and analgesic potentials of the ethanol extract and fractions of L. cyanescens root in mice.

Methodology: The ethanol extract and the partitioned fractions were tested using carrageenan-induced inflammation, xylene–induced ear oedema models as well as on pains induced chemically and thermally in mice.

Results: L. cyanescens root extract and fractions demonstrated anti-inflammatory effects in all the models, suppressed acute oedema as well as exhibited dose and time dependent analgesic properties with butanol fraction showing the highest effects.

Discussion: Since the extract and its fractions significantly affected oedema and pain in the various models of this study, it therefore justify the use of the root traditionally in the treatment of pain and inflammatory diseases.

Keywords: Anti-inflammatory, analgesic, pain, Lonchocarpus cyanescens